Robotic large‐area optical biopsy imaging for automated detection of gastrointestinal cancers tested in tissue phantoms and ex vivo porcine bowel

Gastrointestinal endoscopy is a subjective procedure that frequently requires tissue samples for diagnosis. Contact optical biopsy techniques have the aim of providing direct diagnosis endoscopic areas without excising but lacks wide-area coverage required locating and resecting lesions. This paper presents large-area robotically-deployed imaging platform detection colorectal cancer as an add-on conventional endoscopes. In vitro, in silicon colon phantoms, achieves resolution 0.5 line-pairs per millimeter, while resolving simulated lesions down to 0.75 mm diameter across images (55-103 cm2). Large-area were generated ex vivo porcine colon. The allows centimeter-sized vitro with sub-millimeter resolution, including automatic data segmentation areas. ability robotic actuation spectrum collection also shown animal If successful, this technology could widen access user-independent high-quality early gastrointestinal cancers.